Tuesday, April 30, 2013

Analysis: Emergency care cost estimates are too low

Analysis: Emergency care cost estimates are too low [ Back to EurekAlert! ] Public release date: 29-Apr-2013
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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

PROVIDENCE, R.I. [Brown University] Alternately praised in the aftermath of horrible tragedies as a heroic service and lamented in policy debates as an expensive safety net for people without primary care, emergency medicine is often a hot topic. Despite that importance, an analysis published online April 26 in the Annals of Emergency Medicine finds that national expenditures on emergency care are likely significantly higher than previously thought.

"The ER has become increasingly important as a place where people go for acute unscheduled care, however there has been little rigorous analysis of its cost structure," said paper lead author Dr. Michael Lee, assistant professor of emergency medicine in the Warren Alpert Medical School of Brown University and a physician at Rhode Island Hospital and The Miriam Hospital.

Lee, who had a prior career in economics and finance before training in emergency medicine, co-wrote the analysis with Dr. Brian Zink, professor and chair of the Department of Emergency Medicine at the Alpert Medical School, and Dr. Jeremiah Schuur, assistant professor at Harvard Medical School and director of quality and patient safety for the Department of Emergency Medicine at the Brigham and Women's Hospital.

The challenge of properly accounting for the costs of emergency care, Lee said, becomes crucial as health care financing moves from a fee-for-service model to bundled payments for patient populations or episodes of care.

Clarifying costs

The analysis first examines current estimates of aggregate spending on emergency department (ED) care. The Agency for Healthcare Research and Quality's Medical Expenditure Panel Survey (MEPS) estimates $48.3 billion of spending on emergency care in 2010, or 1.9 percent of the nation's total health care expenditures of $2.6 trillion. With the message that "The total cost is small relative to the entire health care system," the American College of Emergency Physicians has embraced the AHRQ figure in its "Just 2 percent" public relations campaign.

But Lee and his co-authors point out, based on data from other studies, that MEPS undercounts the number of ED visits and the number of ED patients who are admitted to hospitals. Adjusting for those discrepancies using data from a variety of other published sources, the authors estimate that ED costs are between 4.9 percent to 5.8 percent of total health care spending.

The authors went beyond national data sets, including the National Emergency Department Sample, to review ED spending data from a different source: a major national private insurer. The data included charges from doctors and hospitals for imaging, testing, and other procedures. But again there were accounting differences between admitted and discharged patients and a need to account fully for spending from Medicare and Medicaid. The authors' estimate based on this data is ED spending that is 6.2 to 10 percent of total health care spending.

Much of the debate in the academic literature around the expense of ED care has to do with whether the bulk of costs are fixed (e.g., expensive equipment and continuous staffing) or marginal (e.g., flexible staff time, expendable supplies). According to Lee, the cost structure of the ED remains poorly understood and is significantly more complex than what is modeled in existing studies.

As with assessments of total costs, the authors report, the studies vary widely even after adjusting for inflation. Across four major studies over the last three decades, the average cost per patient of an ED visit in 2010 dollars ranged from only $134 to more than $1,000, Lee and colleagues found. Meanwhile, the marginal cost of an ED visit (factoring out the fixed costs), ranged from $150 to $638.

Alternative accounting

The authors instead argue for an accounting based approach to ED costs using a methodology known as "Time-Driven Activity Based Costing (ABC)," which has been applied to health care by Robert Kaplan and Michael Porter, professors at the Harvard Business School.

The method maps all clinical, administrative, and diagnostic steps in a patient encounter and assigns costs to each activity, explicitly accounting for the time spent on each task.

ABC accounting might provide a more realistic and transparent measure of ED costs, Lee said, because the emphasis on time is particularly relevant for emergency medicine.

"The real cost of providing emergency care has to do with accurately measuring the resources that are used, and time is an important variable to take into account," he said.

The authors envision using the methodology to measure the cost of common ED processes or chief complaints, and to compare this to alternative sites such as primary care offices or clinics, he said. They also point out that ABC accounting gives "gives ED managers specific data they can use to improve the value of care by identifying high-cost steps in the process."

Emphasize value, not just cost

The authors acknowledge that an outcome of their analysis reporting higher overall costs for emergency care, may invite further criticism that the expense of emergency care represents unnecessary, inefficient care.

"However, we offer a more sanguine interpretation the high share of spending affirms the importance of emergency medicine within the health care system," they wrote. "With 130 million visits, 28 percent of all acute care visits, and accounting for nearly half of all admissions, emergency medicine should be expected to represent a large share of health care spending."

And Lee cautions, based on other studies, that efforts by private and government payers to divert ER care may not lead to large aggregate savings.

"Diverting nonemergency care may simply shift costs onto primary care offices and clinics which may not have the infrastructure to accommodate a large volume of unscheduled care," Lee said.

Instead there may be more potential for cost savings by focusing on reducing unnecessary diagnostic testing in the ED or unnecessary admissions that originate from the ED.

Lee and his co-authors call for the debate to include value, not just cost.

"More attention should be devoted to quantifying the value of specific aspects of emergency care," they wrote. "Rather than minimize the issue of cost, we should recognize the economic and strategic importance of the ED within the healthcare system and demonstrate that costs are commensurate with value.

Lee acknowledges that this remains a challenge for the field of emergency medicine. "The core of our business is ruling out critical diagnoses. Many of the things we look for are low probability but highly dangerous conditions. The big question is how do you quantify value when your work is often focused on trying to demonstrate the absence of something?"

###


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Analysis: Emergency care cost estimates are too low [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

PROVIDENCE, R.I. [Brown University] Alternately praised in the aftermath of horrible tragedies as a heroic service and lamented in policy debates as an expensive safety net for people without primary care, emergency medicine is often a hot topic. Despite that importance, an analysis published online April 26 in the Annals of Emergency Medicine finds that national expenditures on emergency care are likely significantly higher than previously thought.

"The ER has become increasingly important as a place where people go for acute unscheduled care, however there has been little rigorous analysis of its cost structure," said paper lead author Dr. Michael Lee, assistant professor of emergency medicine in the Warren Alpert Medical School of Brown University and a physician at Rhode Island Hospital and The Miriam Hospital.

Lee, who had a prior career in economics and finance before training in emergency medicine, co-wrote the analysis with Dr. Brian Zink, professor and chair of the Department of Emergency Medicine at the Alpert Medical School, and Dr. Jeremiah Schuur, assistant professor at Harvard Medical School and director of quality and patient safety for the Department of Emergency Medicine at the Brigham and Women's Hospital.

The challenge of properly accounting for the costs of emergency care, Lee said, becomes crucial as health care financing moves from a fee-for-service model to bundled payments for patient populations or episodes of care.

Clarifying costs

The analysis first examines current estimates of aggregate spending on emergency department (ED) care. The Agency for Healthcare Research and Quality's Medical Expenditure Panel Survey (MEPS) estimates $48.3 billion of spending on emergency care in 2010, or 1.9 percent of the nation's total health care expenditures of $2.6 trillion. With the message that "The total cost is small relative to the entire health care system," the American College of Emergency Physicians has embraced the AHRQ figure in its "Just 2 percent" public relations campaign.

But Lee and his co-authors point out, based on data from other studies, that MEPS undercounts the number of ED visits and the number of ED patients who are admitted to hospitals. Adjusting for those discrepancies using data from a variety of other published sources, the authors estimate that ED costs are between 4.9 percent to 5.8 percent of total health care spending.

The authors went beyond national data sets, including the National Emergency Department Sample, to review ED spending data from a different source: a major national private insurer. The data included charges from doctors and hospitals for imaging, testing, and other procedures. But again there were accounting differences between admitted and discharged patients and a need to account fully for spending from Medicare and Medicaid. The authors' estimate based on this data is ED spending that is 6.2 to 10 percent of total health care spending.

Much of the debate in the academic literature around the expense of ED care has to do with whether the bulk of costs are fixed (e.g., expensive equipment and continuous staffing) or marginal (e.g., flexible staff time, expendable supplies). According to Lee, the cost structure of the ED remains poorly understood and is significantly more complex than what is modeled in existing studies.

As with assessments of total costs, the authors report, the studies vary widely even after adjusting for inflation. Across four major studies over the last three decades, the average cost per patient of an ED visit in 2010 dollars ranged from only $134 to more than $1,000, Lee and colleagues found. Meanwhile, the marginal cost of an ED visit (factoring out the fixed costs), ranged from $150 to $638.

Alternative accounting

The authors instead argue for an accounting based approach to ED costs using a methodology known as "Time-Driven Activity Based Costing (ABC)," which has been applied to health care by Robert Kaplan and Michael Porter, professors at the Harvard Business School.

The method maps all clinical, administrative, and diagnostic steps in a patient encounter and assigns costs to each activity, explicitly accounting for the time spent on each task.

ABC accounting might provide a more realistic and transparent measure of ED costs, Lee said, because the emphasis on time is particularly relevant for emergency medicine.

"The real cost of providing emergency care has to do with accurately measuring the resources that are used, and time is an important variable to take into account," he said.

The authors envision using the methodology to measure the cost of common ED processes or chief complaints, and to compare this to alternative sites such as primary care offices or clinics, he said. They also point out that ABC accounting gives "gives ED managers specific data they can use to improve the value of care by identifying high-cost steps in the process."

Emphasize value, not just cost

The authors acknowledge that an outcome of their analysis reporting higher overall costs for emergency care, may invite further criticism that the expense of emergency care represents unnecessary, inefficient care.

"However, we offer a more sanguine interpretation the high share of spending affirms the importance of emergency medicine within the health care system," they wrote. "With 130 million visits, 28 percent of all acute care visits, and accounting for nearly half of all admissions, emergency medicine should be expected to represent a large share of health care spending."

And Lee cautions, based on other studies, that efforts by private and government payers to divert ER care may not lead to large aggregate savings.

"Diverting nonemergency care may simply shift costs onto primary care offices and clinics which may not have the infrastructure to accommodate a large volume of unscheduled care," Lee said.

Instead there may be more potential for cost savings by focusing on reducing unnecessary diagnostic testing in the ED or unnecessary admissions that originate from the ED.

Lee and his co-authors call for the debate to include value, not just cost.

"More attention should be devoted to quantifying the value of specific aspects of emergency care," they wrote. "Rather than minimize the issue of cost, we should recognize the economic and strategic importance of the ED within the healthcare system and demonstrate that costs are commensurate with value.

Lee acknowledges that this remains a challenge for the field of emergency medicine. "The core of our business is ruling out critical diagnoses. Many of the things we look for are low probability but highly dangerous conditions. The big question is how do you quantify value when your work is often focused on trying to demonstrate the absence of something?"

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/bu-aec042913.php

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Sunday, April 28, 2013

Genetically Modified Plants To Produce Natural Lighting

Sounds like you read the Forbes article [forbes.com] and are just repeating what they said.

Especially fun is that the Rats that they fed the fucking roundup pesticide live longer than any of the other rats.

Just because they didn't get cancer from drinking the pesticide doesn't mean the pesticide-resistant GMO crops are safe.

And that's really the problem with GMO, testing sucks. There are very few, if any, meaningful and rigorous tests. Lots of short term test and tons of grandfathering in genes because they came from other organisms where they were not a problem. But when it comes to comprehensive testing that could reassure the general population of the safety of GMO crops, there just isn't any.

Given the history we have with things like thalidomide, DDT, leaded gasoline, fen-phen, etc it is not unreasonable that people be genuinely concerned about GMO crops, especially given how widespread they've become with such little public notice. Dismissing those concerns as the equivalent of creation science is at least as bad as creationism itself because it is just another misplaced faith.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/WxwuuJ6JvnM/story01.htm

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Two bizarre endings mar UFC 159 prelims

The UFC debut of two Strikeforce light heavyweights was spoiled by a odd ending. Ovince St-Preux beat Gian Villante in a majority technical decision after the fight was stopped because of a poke to the eye.

After a back-and-forth, but not entirely thrilling bout, St-Preux threw a punch and accidentally poked Villante in the eye. Villante stepped back and crouched down, indicating to referee Kevin Mulhall that there was a problem with the eye. Mulhall asked Villante if he could see, and Villante said no, he couldn't see.

At that point, Mulhall waved his arms and the fight was stopped. Villante protested, but the fight was over. Because the round had started, it had to be judged. The scores were 30-28, 29-28 and 29-29 in St-Preux's favor.

?I couldn?t see. He did poke me in the eye so I don?t know," Villante said after the fight. "He said the fight was over and I didn?t expect that because I was just reacting to his question. I got poked and my eye was closed up so I thought he would stop it but he didn?t, he just kind of looked at me. I don?t understand how you score thirty seconds of a round and that?s how I lost? We were just getting going and I got poked in the eye. I don?t know what to say.?

Mulhall's stoppage adhered to the eyepoke rule, if not literally, then in spirit. When a fighter says he can't see, the fight is stopped. However, Mulhall could have used better communication and followed procedures. It would have been better if he explained to Villante that he didn't have time to recover and that the fight would be stopped if he said he couldn't see.

UFC 159's weird streak continued in the very next bout. Rustam Khabilov and Yancy Medeiros' fight was stopped halfway through the first round. Medeiros defended a Khabilov takedown attempt, but hit his hand awkwardly. His thumb ended up pointing a way thumbs are not supposed to point and the bout was stopped at 2:32 of the first round.

Two weird endings marred the preliminary card, but the UFC rarely lets a weird ending go. Quite often, these fights get a rematch, so don't be shocked if you see these fights happen again on a card this summer.

Other popular content on Yahoo! Sports:
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Source: http://sports.yahoo.com/blogs/mma-cagewriter/two-bizarre-endings-mar-ufc-159-prelims-020815615.html

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Saturday, April 27, 2013

UK shale gas bonanza 'not assured'

Shale gas in the UK could help secure domestic energy supplies but may not bring down prices, MPs report.

The US boom in shale gas has brought energy prices tumbling and revitalised heavy industry, but the Energy and Climate Change Committee warns conditions are different in Britain.

The MPs say the UK's shale gas developers will face technological uncertainties with different geology.

And public opinion may also be more sceptical, they add.

The UK is a more densely populated landscape, and shale gas operations will be closer to settlements as a consequence.

'Cash sweeteners'

The MPs believe operators will have to overcome potentially tighter regulations.

What is more, the extent of recoverable resources in the UK is also unknown, so the report concludes that it is too soon to say whether shale gas will achieve US-style levels of success.

Continue reading the main story

?Start Quote

Fracking is dirty and unnecessary - it's little wonder so many communities are in opposition?

End Quote Tony Bosworth Friends of the Earth

The MPs argue that this means the Treasury cannot afford to base the UK?s energy strategy on the expectation of cheap British shale gas.

They urge the government to stop "dithering" over energy policy, though, and to ensure there is a system to rebut what "scare stories" may arise over the environmental impacts of shale gas.

And they applaud the government's decision to offer cash sweeteners to people near shale gas facilities.

Success with shale gas will reduce dependence on imports and increase tax revenues, they say, but there is a downside: if it takes off, shale gas will shatter the UK's statutory climate change targets unless the government moves much faster with carbon capture and storage technology.

Tim Yeo, chairman of the Energy and Climate Change Committee, said: "It is still too soon to call whether shale gas will provide the silver bullet needed to solve our energy problems.

"Although the US shale gas has seen a dramatic fall in domestic gas prices, a similar 'revolution' here is not certain."

Tony Bosworth, from Friends of the Earth, responded: "This does little to back the case for a UK shale gas revolution.

"Fracking is dirty and unnecessary ? it's little wonder so many communities are in opposition. We should be building an affordable power system based on our abundant clean energy from the wind, waves and sun.?

'Front and centre'

And Jenny Banks from WWF-UK said: "It's simply impossible to keep global warming below 2C and burn all known fossil fuel reserves ? let alone exploit unconventional reserves like shale gas.

"In other words, the climate impacts of new fossil fuel developments must be front and centre of any decision on shale gas, not a secondary concern."

But the government's chief energy scientist, David MacKay, has warned that the UK would need to increase its nuclear fleet four-fold or its wind energy 20-fold to decarbonise heavy industry.

Both these options appear improbable, so the government is most likely to continue to give gas a prominent role in its energy strategy.

Ken Cronin, chief executive of the UK Onshore Operators Group, said: "The industry is pleased that the Committee supports our view that community engagement is key to public acceptance of shale gas exploration and that communities should share in the benefits of development."

Follow Roger on Twitter @rharrabin

Source: http://www.bbc.co.uk/news/science-environment-22300050#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Friday, April 26, 2013

UN approves peacekeeping force for Mali

UNITED NATIONS (AP) ? The Security Council unanimously approved a new U.N. peacekeeping force for Mali on Thursday to help restore democracy and stabilize the northern half of the country, which was controlled by Islamist jihadists until a France-led military operation ousted them three months ago.

The resolution authorizes the deployment of a U.N. force comprising 11,200 military personnel and 1,440 international police with a mandate to help restore peace, especially in northern cities. The U.N. peacekeepers are not authorized to undertake offensive military operations or chase terrorists in the desert, roles that will continue to be carried out by France under an agreement with Mali.

The U.N. peacekeepers would take over from a 6,000-member African-led mission now in Mali on July 1, although the deployment date is subject to change if security conditions deteriorate.

French Foreign Minister Laurent Fabius welcomed the resolution, saying it "confirms the unanimous support of the international community for the stabilization of Mali as well as the intervention of France and the nations of the region to help this country."

Mali fell into turmoil after a March 2012 coup created a security vacuum that allowed secular Tuareg rebels to take over half of the country's north as a new homeland. Months later, the rebels were kicked out by Islamic jihadists who imposed strict Shariah law in the north.

When the Islamists started moving into government-controlled areas in the south, France launched a military offensive on Jan. 11 to oust them. The fighters, many linked to al-Qaida, fled the major towns in the north but many went into hiding in the desert and continue to carry out attacks.

Mali's Foreign Minister Tieman Hubert Coulibaly called the resolution "an important step" to help stem the activities of terrorists and armed groups, promote dialogue and reconciliation between Malians, and ensure peace throughout the country.

"Small cells of armed terrorists and rebels continue to represent a serious threat to instability and the territorial integrity of Mali as well as to peace and security in the region," he told the council after the vote. "This is why the government welcomes the international community to take active measures to deter and to prevent the return of armed groups."

French officials say combat in Mali has all but stopped and its intervention has severely eroded the insurgents' ability to stage large-scale operations such by deploying dozens of nimble pickup trucks to seize territory ? which they did as late as January.

Before the French onslaught began, diplomats and defense officials in Paris estimated that the al-Qaida-linked militants could count about 2,000 fighters. French diplomats said Thursday that France estimates that about 700 of those have been killed, another 200 have been taken prisoner in Mali ? while the rest are hiding out or have fled elsewhere in the region, including southern Libya.

The main jobs of the new U.N. force will be to stabilize key population centers in the north, support the re-establishment of government authority throughout the country, and assist the transitional authorities in restoring constitutional order, democratic governance and national unity.

The resolution authorizes the force "to take active steps to prevent the return of armed elements" to the northern areas, to rebuild the Malian police, as well as disarm and demobilize former combatants.

Because of the continuing insecurity in the north, the resolution requires the Security Council to review the July 1 deployment date for the U.N. force within 60 days to assess whether terrorists pose a major threat in areas where peacekeepers would operate or if international military forces are conducting major combat operations in those areas. If so, the council could delay the deployment.

The new U.N. force has a robust mandate to take defensive action ? but not offensive military operations, a point stressed by Russia's U.N. Ambassador Vitaly Churkin who said "there must be a clear division between peacekeeping and peace enforcement."

While the mission won't be conducting offensive or anti-terrorist operations, U.N. peacekeeping chief Herve Ladsous told reporters "we know it's going to be a fairly volatile environment" and there will certainly be some attacks against peacekeepers where they will have to defend themselves.

He said most of the 6,000 African troops currently in Mali will become part of the new U.N. Multidimensional Integrated Stabilization Mission in Mali, to be known as MINUSMA.

France is gradually easing back on its presence in Mali ? currently just under 4,000 troops ? and French officials said they expect to have roughly 1,000 there by year-end. Some 750 of those will be devoted to fighting the insurgent groups, the rest will be 150 French peacekeepers in the U.N. force, and 100 or so trainers for the Malian military, the officials said.

The U.N. force will also operate alongside a European Union mission that is providing military training to the Malian army, which is ineffective, ill-equipped and divided.

France's U.N. Ambassador Gerard Araud said that when the Malian army is able to do its job and ensure the sovereignty of the country, the peacekeeping force will leave.

Besides improving the military and security, he said, "what we have to encourage, what we have to support, is a political process of reconciliation of all Malians."

Araud said pursing a national dialogue will be a top priority when a new U.N. envoy to Mali is appointed. French diplomats, speaking on condition of anonymity because no announcement has been made, said the frontrunner for the job is Albert Koenders of the Netherlands, currently the secretary-general's special envoy for Ivory Coast.

___

Associated Press Writer Jamey Keaten in Paris contributed to this report

Source: http://news.yahoo.com/un-approves-peacekeeping-force-mali-145148699.html

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Mars Rover Channels Inner 12-Year-Old, Defaces Red Planet

Source: http://www.thehollywoodgossip.com/2013/04/mars-rover-channels-inner-12-year-old-defaces-red-planet/

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Inhibiting enzymes in the cell may lead to development and proliferation of cancer cells

Apr. 25, 2013 ? Blocking certain enzymes in the cell may prevent cancer cell division and growth, according to new findings from researchers at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The discovery is published in the April 25, 2013 issue of the journal Molecular Cell.

In order to divide, a cell needs to create copies of its genetic material to provide to the new cells, called the "daughter" cells. Several enzymes in the cells, called cyclin dependent kinases (CDKs), act as the traffic cops for this process, making sure that DNA is copied correctly and determining when the cell should move into the next stage of division. Each CDK has a different responsibility during cell division. For example, CDK1 promotes the segregation of DNA into the new daughter cells; CDK4 and 6 act on a tumor suppressor gene; and CDK7 plays an important role in DNA transcription into RNA.

When the cell reaches a stage called the "restriction point," it has passed the threshold where division can be safely stopped -- the point of no return. For years, scientists have been working to inhibit the activity of these CDK enzymes in cancer cells before they reach the restriction point, so that that cell division stops and cancer cannot proliferate.

Led by Robert Fisher, MD, PhD, Associate Professor of Structural and Chemical Biology at Mount Sinai, the research team evaluated human colon cancer cells in a petri dish to assess the activity of CDKs. Previous research had shown that CDK7 was a critical enzyme in cell division, but the team wanted to learn how its activity influenced other CDKs; specifically, CDK4 and CDK6, two critical enzymes that act prior to the restriction point and whose regulation is not completely understood.

"While we know that CDK7 plays an essential role in all cells, its precise activity and specific targets in the cell remained unclear," said Dr. Fisher. "CDK4 and CDK6 have also been elusive targets in our research, and we wanted to learn how CDK7 affected them."

Turning off CDK4 and CDK6 has been shown to be effective in blocking division of some cancer cells and is currently being tested in clinical trials. The new study suggests that turning off CDK7 might be equally or more effective, making all three enzymes viable therapeutic targets for the prevention of cancer cell proliferation. Taking advantage of a unique method they developed to control CDK activity in human cells, the research team found that when they "turned off" the activity of CDK7, CDK4 and CDK6 were also inactivated rapidly. This makes sense, because CDK7 is able to activate both CDK4 and CDK6 in the test tube, enabling them to modify a key tumor suppressor protein, which is thought to be how they promote cancer cell growth and division.

"These findings complete the story of CDK activation in human cells, in which one CDK is capable of activating others," said Dr. Fisher. "Now, we want to evaluate what signaling pathway earlier in the cell division process leads to CDK7 activation, so that it can in turn activate CDK4 and CDK6. This pathway may be an important therapeutic target for cancer, and possibly other diseases as well."

Next, Dr. Fisher and his team plan to find out what is happening upstream, or earlier, in the cell division process that turns up the activity of CDK7, and also to learn more specifically how it is interacting with CDK4 and CDK6.

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The above story is reprinted from materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Miriam?Merzel Schachter, Karl?A. Merrick, St?phane Larochelle, Alexander Hirschi, Chao Zhang, Kevan?M. Shokat, Seth?M. Rubin, Robert?P. Fisher. A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression. Molecular Cell, 2013; 50 (2): 250 DOI: 10.1016/j.molcel.2013.04.003

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/NR89oRs7grY/130425132643.htm

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Thursday, April 25, 2013

Behold, The Bastard Child Of Crocs: Crosskix

Source: http://www.getoutdoors.com/goblog/index.php?/archives/4592-Behold,-The-Bastard-Child-Of-Crocs-Crosskix.html

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New Jersey Attorneys Go To Capitol Hill And Elder Law Retreat In ...

Moorestown, NJ (Law Firm Newswire) April 24, 2013 ? The Begley Law Group?s continued commitment to the rights of their clients includes attending and presenting at professional seminars.

The attorneys at Begley Law Group recently attended two significant outreach efforts as part of their ongoing support of clients, including individuals with special needs and their families, and the elderly.

On April 15-16, 2013, Kristen L. Behrens and Tom Begley, Jr., of Begley Law Group attended the Special Needs Alliance Spring Meeting in Washington, DC, where they heard speakers from the Social Security Administration and Easter Seals on Affordable Care Act and they participated in Hill Day, where members of the Alliance visited their Congressman and Senators.

?The visitations were part of an outreach to emphasize to U.S. Senators and representatives the place that many government programs have in the lives of adults and children with disabilities,? commented New Jersey elder law attorney Thomas D. Begley, Jr.

Advocates for individuals with special needs work during Hill Day to make an in-person connection with leaders and staff to better foster relationships that can help support those individuals in need of federal social services.

On April 18-19, 2013 Tom Begley, Jr., and Dana E. Bookbinder of Begley Law attended the New Jersey Elder Law Retreat held in Long Branch, NJ. Tom also presented on the Future of Elder and Disability Law. Presented by the NJSBA Elder Law & Disability Law Section and the New Jersey Institute for Continuing Legal Education,?The New Jersey Elder Law Retreat was designed to keep attorneys abreast of legal developments and support their efforts to maintain a high level of professional competence in elder law. The New Jersey Institute for Continuing Legal Education is well-regarded for the consistently high quality of the seminars it offers, and had been designated by the Supreme Court of the State of New Jersey as a place to provide the Skills and Methods Course, a part of the bar admission requirements until 2010.

Begley Law Group is a premier law firm with more than 75 years of experience in the New Jersey area. Every partner at Begley Law Group is a recipient of the prestigious New Jersey SuperLawyers award. They are experts at elder and disability law and keenly aware of the latest legislative developments that are critical for their clients.

To learn more about Begley Law Group or to contact a New Jersey estate planning lawyer or Philadelphia estate planning lawyer, call 1.800.533.7227 or visit www.begleylawgroup.com.

Colleen Caruso
Begley Law Group, P.C.
509 S. Lenola Road, Building 7
Moorestown, NJ 08057
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Source: http://www.lawfirmnewswire.com/2013/04/new-jersey-attorneys-go-to-capitol-hill-and-elder-law-retreat-in-extensive-outreach-efforts/

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After Launching #Music, Kevin Thau Becomes Latest Employee To Leave Twitter For Biz Stone's Jelly

Image (1) kevin-thau.png for post 37462Less than one week after Twitter Music's launch, Kevin Thau, the man responsible for the standalone app, is leaving the company to become COO of Jelly, Twitter co-founder Biz Stone's mysterious, mobile-focused startup, according to AllThingsD.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/ic-0pAkAX1Y/

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Wednesday, April 24, 2013

Earth's cooling came to sudden halt in 1900, study shows

An international study used tree rings and pollen to build the first?record of global climate change, continent by continent, over 2,000 years.

By Pete Spotts,?Staff writer / April 23, 2013

Emperor penguins walk across sea ice near Ross Island, Antarctica, in this 2012 photo released by Thomas Beer. The continent's pristine habitat provides a laboratory for scientists studying the effects of climate change.

Courtesy Thomas Beer/AP/File

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A reconstruction of 2,000 years of global temperatures shows that a long-term decline in Earth's temperatures ended abruptly about 1900, replaced by a warming trend that has continued despite the persistence into the 20th century of the factors driving the cooling, according to a new study.

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Indeed, for several continents, the increase in global average temperatures from the 19th century to the 20th was the highest century-to-century increase during the 2,000-year span, the study indicates. It's the first study to attempt building a millennial-scale climate history, continent by continent.

The research wasn't designed to identify the cause of the warming trend, which climate researchers say has been triggered by a buildup of greenhouse gases ? mainly carbon dioxide ? as humans burned increasing amounts of fossil fuel and altered the landscape in ways that released CO2.

Still, it's hard to explain 20th-century warming without including the influence of rising CO2 levels, because the factors driving the cooling were still present, notes Darrell Kaufman, a researcher at Northern Arizona University and one of the lead authors on the paper formally reporting the results in the journal Nature Geoscience.

The study, five years in the making, drew on the work of 87 scientists in 24 countries as part of the International Geosphere-Biosphere Program. One goal of the 27-year-old program is to gain a deeper understanding of Earth's climate history and the factors that contribute to climate variability.

The study used nature's proxies for thermometers ? tree rings, pollen, and other natural temperature indicators ? to build continent by continent a coordinated record of temperature changes during the past two millenniums.

Scientists use this proxy approach to reach further into the climate's temperature history than the relatively short thermometer record allows. Such efforts aim to put today's climate into a deeper historical context as well as to identify the duration and possible triggers for natural swings that the climate undergoes over a variety of time scales.

Last March, for instance, a team led by Shaun Marcott at Oregon State University used climate proxies to build a global temperature record reaching back 1,200 years ? one that also noted the pre-1900 cooling trend.

Until now, however, the proxy approach has been used to reconstruct changes in global-average and hemisphere-wide temperatures, Dr. Kaufman explains.

"There was very little information about past climate variability at the regional scale," he says. Yet the team notes that no one lives in a global-average world. People live in specific regions where geography plays a vital role in shaping the climate patterns they experience.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/s_CQlowEYIE/Earth-s-cooling-came-to-sudden-halt-in-1900-study-shows

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Suspect in Canada terror plot denies charges

In this courtroom sketch, Raed Jaser appears in court in Toronto on Tuesday, April 23, 2013. Jaser, 35, and Chehib Esseghaier, 30, were arrested and charged Monday in what the RCMP said was the first known al-Qaida terror plot in Canada. (AP Photo/The Canadian Press, John Mantha)

In this courtroom sketch, Raed Jaser appears in court in Toronto on Tuesday, April 23, 2013. Jaser, 35, and Chehib Esseghaier, 30, were arrested and charged Monday in what the RCMP said was the first known al-Qaida terror plot in Canada. (AP Photo/The Canadian Press, John Mantha)

Security officials check a man at a courthouse in Montreal on Tuesday, April 23, 2013. Reed Jaser, one of two men accused of plotting a terrorist attack against a Canadian passenger train with support from al-Qaida elements in Iran, made a brief court appearance Tuesday but did not enter a plea. Canadian investigators say Jaser, 35, and his suspected accomplice Chiheb Esseghaier, 30, received ?directions and guidance? from members of al-Qaida. The case prompted an immediate response from Iran, which denied any involvement and said groups such as al-Qaida do not share Iran?s ideology. (AP Photo/The Canadian Press, Ryan Remiorz)

Security officials check a man at a courthouse in Montreal on Tuesday, April 23, 2013. Reed Jaser, one of two men accused of plotting a terrorist attack against a Canadian passenger train with support from al-Qaida elements in Iran, made a brief court appearance Tuesday but did not enter a plea. Canadian investigators say Jaser, 35, and his suspected accomplice Chiheb Esseghaier, 30, received ?directions and guidance? from members of al-Qaida. The case prompted an immediate response from Iran, which denied any involvement and said groups such as al-Qaida do not share Iran?s ideology. (AP Photo/The Canadian Press, Ryan Remiorz)

A man walks his dog past a mosque where Chiheb Esseghaier, one of the two accused in an alleged plot to bomb a Via passenger train, used to attend Tuesday, April 23, 2013 in Montreal. Canadian investigators say Raed Jaser, 35, and his suspected accomplice Chiheb Esseghaier, 30, received "directions and guidance" from members of al-Qaida in Iran. Iran said it had nothing to do with the plot, and groups such as al-Qaida do not share Iran's ideology. (AP Photo/The Canadian Press, Ryan Remiorz)

(AP) ? A man accused of plotting with al-Qaida members in Iran to derail a train in Canada rejected the charges and said Tuesday that authorities were basing their conclusions on appearances. Law enforcement officials in the U.S. said the target was a train that runs between New York City and Canada.

Canadian investigators say Raed Jaser, 35, and his suspected accomplice Chiheb Esseghaier, 30, received guidance ? but no money ? from members of al-Qaida in Iran. Iran released a statement saying it had nothing to do with the plot, even though there were no claims in Canada that the attacks were sponsored directly by Iran.

But the case raised questions about the extent of Shiite-led Iran's relationship with the predominantly Sunni Arab terrorist network. It also renewed attention on Iran's complicated history with the terror group, which ranges from outright hostility to alliances of convenience and even overtures by Tehran to assist Washington after the Sept. 11, 2001, attacks on the United States.

"We oppose any terrorist and violent action that would jeopardize lives of innocent people," Iranian Foreign Ministry spokesman Ramin Mehmanparast said Tuesday.

Charges against the two men in Canada include conspiring to carry out an attack and murder people in association with a terrorist group. Police ? tipped off by an imam worried by the behavior of one of the suspects ? said it was the first known attack planned by al-Qaida in Canada.

Law officials in New York with knowledge of the investigation told The Associated Press the attack was to take place on the Canadian side of the border. They are not authorized to discuss the investigation and spoke only on condition of anonymity.

Amtrak and Via Rail Canada jointly operate routes between the United States and Canada, including the Maple Leaf from New York City to Toronto.

Mayor Michael Bloomberg said Canada has kept New York posted on the investigation.

"I can just tell you that you are probably safer in New York City than you are in any other big city," Bloomberg told reporters Tuesday without discussing details.

In a brief court appearance in Montreal, a bearded Esseghaier declined to be represented by a court-appointed lawyer. He made a brief statement in French in which he called the allegations against him unfair.

"The conclusions were made based on facts and words which are only appearances," he said in a calm voice after asking permission to speak.

Jaser appeared in court earlier Tuesday in Toronto and also did not enter a plea. He was given a new court date of May 23. He had a long beard, wore a black shirt with no tie, and was accompanied by his parents and brother. The court granted a request by his lawyer, John Norris, for a publication ban on future evidence and testimony.

Norris questioned the timing of the arrests, pointing to ongoing debates in the Canadian Parliament over a new anti-terrorism law that would expand the powers of police and intelligence agencies.

He said his client would "defend himself vigorously" against the accusations, and noted Jaser was a permanent resident of Canada who has lived there for 20 years. Norris refused to say where Jaser was from, saying that revealing his nationality in the current climate amounted to demonizing him.

Canadian police also declined to release the men's nationalities, saying only they had been in Canada a "significant amount of time."

Muslim community leaders who were briefed by the RCMP ahead of Monday's announcement of the arrest said they were told one of the suspects is Tunisian and the other from the United Arab Emirates.

Esseghaier's LinkedIn profile lists him as having studied in Tunisia before moving to Canada, where he was pursuing a PhD in nanotechnology at the National Institute of Scientific Research, a spokeswoman at the training university confirmed.

In Abu Dhabi, a UAE source informed about the attack plot said there was "no UAE citizen" with the name Raed Jaser. The source spoke on condition of anonymity because he was not authorized to brief media.

The investigation surrounding the planned attack was part of a cross-border operation involving Canadian law enforcement agencies, the FBI and the U.S. Department of Homeland Security. Canadian police said the men never got close to carrying out the attack.

The warning first came from an imam in Toronto, who in turn was tipped off by suspicious behavior on the part of one of the suspect.

"I was involved in alerting police about the suspect. I made some calls on behalf of the imam over a year ago," Toronto lawyer Naseer Syed said. He would not say what, exactly made the imam suspicious.

"The Muslim community has been cooperating with authorities for a number of years and people do the right thing when there is reason to alert authorities," Syed said, adding that he was speaking for the imam, who wished to remain anonymous.

___

Associated Press writers Charmaine Noronha in Ontario, Shingler in Montreal, Tom Hays and Jennifer Peltz in New York, Kimberly Dozier in Washington and Brian Murphy in the United Arab Emirates contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-23-CN-Canada-Terror-Plot/id-818a6768d5e448a1881c88ad6c80371d

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Weiner back on Twitter, the epicenter of his prior downfall (cbsnews)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

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Tuesday, April 23, 2013

NYC proposes raising age for cigarette purchases

In this March 18, 2013 file photo cigarette packs are displayed for sale at a convenience store in New York. No one under 21 would be able to buy cigarettes in New York City under a proposal unveiled Monday, April 22, 2013 to make the city the most populous place in America to set the minimum age that high. (AP Photo/Mark Lennihan, file)

In this March 18, 2013 file photo cigarette packs are displayed for sale at a convenience store in New York. No one under 21 would be able to buy cigarettes in New York City under a proposal unveiled Monday, April 22, 2013 to make the city the most populous place in America to set the minimum age that high. (AP Photo/Mark Lennihan, file)

(AP) ? No one under 21 would be able to buy cigarettes in the city under a proposal unveiled Monday to make it the most populous place in America to set the minimum age that high.

Extending a decade of moves to crack down on smoking in the nation's largest city, the measure aims to stop young people from developing a habit that remains the leading preventable cause of death, City Council Speaker Christine Quinn said as she announced the plan. Eighty percent of the city's smokers started lighting up before they were 21, officials say.

"The point here is to really address where smoking begins," she said, flanked by colleagues and the city's health commissioner. With support in the council and Mayor Michael Bloomberg's backing, the proposal has the political ingredients to pass.

But it may face questions about its effectiveness and fairness. A retailers' representative suggested the measure would simply drive younger smokers to neighboring communities or corner-store cigarette sellers instead of city stores, while a smokers' rights advocate called it "government paternalism at its worst."

Under federal law, no one under 18 can buy tobacco anywhere in the country. Four states and some localities have raised the age to 19, and at least two communities have agreed to raise it to 21.

A similar proposal has been floated in the Texas Legislature, but it's on hold after a budget board estimated it would cost the state more than $42 million in cigarette tax revenue over two years.

To public health and anti-smoking advocates, the cost to government is far outstripped by smoking's toll on human lives.

They say a higher minimum age for buying tobacco discourages, or at least delays, young people from starting smoking and thereby limits their health risks.

"Curtailing smoking among these age groups is critical to winning the fight against tobacco and reducing the deaths, disease and health care costs it causes," said Susan M. Liss, executive director of the Campaign for Tobacco-Free Kids.

Smoking has become less prevalent overall in New York City over the last decade but has plateaued at 8.5 percent among the city's public high school students since 2007. An estimated 20,000 of them smoke today.

It's already illegal for many of them to buy cigarettes, but raising the minimum age would also bar slightly older friends from buying smokes for them.

City officials cited statistical modeling, published in the journal Health Policy, that estimated that raising the tobacco purchase age to 21 nationally could cut the smoking rate by two-thirds among 14-to-17-year-olds and by half among 18-to-20-year-olds over 50 years. Texas budget officials projected a one-third reduction in tobacco product use by 18-to-20-year-olds.

A higher minimum tobacco purchase age could cut into sales that make up 40 percent of gross revenues for the average convenience store, said Jeff Lenard, a spokesman for the National Association of Convenience Stores. But he suggested younger smokers might just go outside the city ? the minimum age is 19 in nearby Long Island and New Jersey, for instance ? or to black-market merchants.

To smoker Audrey Silk, people considered old enough to vote and serve in the military should be allowed to decide whether to use cigarettes.

"Intolerance for anyone smoking is the anti-smokers' excuse to reduce adults to the status of children," said Silk, who founded a group that has sued the city over previous tobacco restrictions.

Advocates for the measure say the parallel isn't voting but drinking. They cite laws against selling alcohol to anyone under 21.

The nation's largest cigarette maker, Altria Group Inc., had no immediate comment, spokesman David Sutton said. He has previously noted that the Richmond, Va.-based company, which produces the top-selling Marlboro brand, supported federal legislation that in 2009 gave the Food and Drug Administration the power to regulate tobacco products, which includes various retail restrictions.

Representatives for R.J. Reynolds Tobacco Co. didn't immediately respond to phone and email inquiries. Based in Winston-Salem, N.C., it makes Camel and other brands.

The age limit is already 21 in Needham, Mass., and is headed toward 21 in another Boston suburb, Canton. The Canton Board of Health agreed to the change this month, but it's not yet implemented, said Public Health Director John L. Ciccotelli.

Plans call for an annual study of whether smoking declines among Canton high-school students ? and eliminating the measure in five years if it doesn't, he said.

In Needham, the high school smoking rate has dropped from about 13 percent to 5.5 percent since the 21-year-old threshold took effect in 2006, Public Health Director Janice Berns said. It's not clear how much of the decline is due to the age limit.

Since Bloomberg took office in 2002, New York City helped impose the highest cigarette taxes in the country, barred smoking at parks and on beaches and conducted sometimes graphic advertising campaigns about the hazards of smoking.

Last month, Bloomberg proposed to keep cigarettes out of sight in stores and to stop shops from taking cigarette coupons.

A council hearing on those and the age limit proposal is set for May 2.

Several New York City smoking regulations have survived court challenges. But a federal appeals court said last year that the city couldn't force tobacco retailers to display gruesome images of diseased lungs and decaying teeth.

Quinn, a leading Democratic candidate to succeed Bloomberg next year, has often been perceived as an ally of his.

Bloomberg also has pushed a number of other pioneering public-health measures, such as compelling chain restaurants to post calorie counts on their menus, banning artificial trans fats in restaurants and attempting to limit the size of sugary drinks. A court struck down the big-beverage rule last month, but the city is appealing.

While Bloomberg has led many anti-smoking initiatives, this one arose from the council ? particularly Councilman James Gennaro, who lost his mother to lung cancer after she smoked for decades.

___

Associated Press writer Michael Felberbaum in Richmond, Va., contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-22-Anti-Smoking-NYC/id-67edfd1cb42a406f848ea9945fe6baae

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Put an Entire Galaxy Under Your Office Chair

A floor mat is unfortunately a must-have accessory if you don't want your office chair trampling down carpet, or tearing up a wooden floor. But thankfully you no longer have to just opt for a boring sheet of plastic. Underfoot Media creates chair mats printed with stunning images of the universe, so rolling over to get a printout feels like soaring across the galaxy. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/J7j-q_Pz56M/put-an-entire-galaxy-under-your-office-chair

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Scientist identifies protein molecule used to maintain adult stem cells in fruit flies

Apr. 22, 2013 ? Understanding exactly how stem cells form into specific organs and tissues is the holy grail of regenerative medicine. Now a UC Santa Barbara researcher has added to that body of knowledge by determining how stem cells produce different types of "daughter" cells in Drosophila (fruit flies). T

he findings appear today in the Proceedings of the National Academy of Sciences.

Denise Montell, Duggan Professor of Molecular, Cellular and Developmental Biology at UCSB, and colleagues studied the ovaries of fruit flies in order to see stem cells in their natural environment. Because these organisms are excellent models for understanding stem cell biology, researchers were able to shed light on the earliest stages of follicle cell differentiation, a previously poorly understood area of developmental biology. "It is clear that the fundamental principles that control cell behavior in simple animals are conserved and control the behavior of our cells as well," she said. "There is so much we can learn by studying simple organisms."

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal. "Having identified this important protein molecule in fruit flies, we can test whether the human version of the protein is important for stem cells and their daughters as well," said Montell. "The more we know about the molecules that govern stem cell behavior, the closer we will get to controlling these cells."

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters). What's more, they identified Cas as a critical, tissue-specific target of Hh signaling, which not only plays a key role in maintaining follicle stem cells but also assists in the diversification of their progeny.

The study also shows that complementary patterns of Cas and Eya reveal the gradual differentiation of polar and stalk precursor cells at the earliest stages of their development. In addition, it provides a marker for cell fates and insight into the molecular and cellular mechanisms by which FSC progeny diverge into distinct fates.

Follicle cells undergo a binary choice during early differentiation. Those that turn into specialized cells found at the poles of egg chambers go on to make two cell types: polar and stalk. The three genes, Cas, Eya and Hh, work in various combinations, sometimes repressively, to determine which types of cells are formed. Cas is required for polar and stalk cell fate specification, while Eya is a negative regulator of these cells' fate. Hh is necessary for Cas to be expressed, and Hh signaling is essential to repress Eya.

"If you just had one of these markers, it was hard to tell what's going on," explained Montell. "All the cells looked the same and you had no idea when or how the process occurred. But now we can actually see how the cells acquire different identities."

Hh also plays many roles in embryonic development, adult homeostasis, birth defects, and cancer. Hh antagonists are currently in clinical trials for the treatment of several types of cancer. However, Hh signaling is important in so many different cell types and tissues that systemic delivery of such inhibitors may cause serious side effects. Therefore identifying the essential, tissue-specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.

Someday, targeted inhibition of Hh signaling may be effective in the treatment and prevention of many types of human cancers.

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The above story is reprinted from materials provided by University of California - Santa Barbara, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yu-Chiuan Chang, Anna C.-C. Jang, Cheng-Han Lin, and Denise J. Montell. Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis. PNAS, April 22, 2013 DOI: 10.1073/pnas.1300725110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/3pFbpMK9yM4/130422154949.htm

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Monday, April 22, 2013

Interrogators wait to query wounded bomb suspect

Police officers stand near statues of former Boston Red Sox greats, from left, Ted Williams, Bobby Doerr, Johnny Pesky and Dom DiMaggio during a baseball game between the Kansas City Royals and the Boston Red Sox, the first game held in the city following the Boston Marathon explosions, Saturday, April 20, 2013, in Boston. Police captured Dzhokhar Tsarnaev, 19, the surviving Boston Marathon bombing suspect, late Friday, after a wild car chase and gun battle earlier in the day left his older brother dead. (AP Photo/Julio Cortez)

Police officers stand near statues of former Boston Red Sox greats, from left, Ted Williams, Bobby Doerr, Johnny Pesky and Dom DiMaggio during a baseball game between the Kansas City Royals and the Boston Red Sox, the first game held in the city following the Boston Marathon explosions, Saturday, April 20, 2013, in Boston. Police captured Dzhokhar Tsarnaev, 19, the surviving Boston Marathon bombing suspect, late Friday, after a wild car chase and gun battle earlier in the day left his older brother dead. (AP Photo/Julio Cortez)

This Friday, April 19, 2013 image made available by the Massachusetts State Police shows 19-year-old Boston Marathon bombing suspect, Dzhokhar Tsarnaev, hiding inside a boat during a search for him in Watertown, Mass. He was pulled, wounded and bloody, from the boat parked in the backyard of a home in the Greater Boston area. (AP Photo/Massachusetts State Police)

An official wearing SWAT gear walks behind a fenced off area outside of Fenway Park during a baseball game between the Kansas City Royals and the Boston Red Sox, the first game held in the city following the Boston Marathon explosions, Saturday, April 20, 2013, in Boston. Police captured Dzhokhar Tsarnaev, 19, the surviving Boston Marathon bombing suspect, late Friday, after a wild car chase and gun battle earlier in the day left his older brother dead. (AP Photo/Julio Cortez)

This Friday, April 19, 2013 image made available by the Massachusetts State Police shows 19-year-old Boston Marathon bombing suspect, Dzhokhar Tsarnaev, hiding inside a boat during a search for him in Watertown, Mass. He was pulled, wounded and bloody, from the boat parked in the backyard of a home in the Greater Boston area. (AP Photo/Massachusetts State Police)

This Friday, April 19, 2013 image made available by the Massachusetts State Police shows a police vehicle probing the boat where 19-year-old Boston Marathon bombing suspect, Dzhokhar Tsarnaev, was hiding in Watertown, Mass. He was pulled, wounded and bloody, from the boat parked in the backyard of a home in the Greater Boston area. (AP Photo/Massachusetts State Police)

(AP) ? As the lone surviving suspect in the Boston Marathon bombing lay hospitalized under heavy guard, the American Civil Liberties Union and a federal public defender raised concerns about investigators' plan to question 19-year-old Dzhokhar Tsarnaev without reading him his Miranda rights.

What Tsarnaev will say and when are unclear ? he remained in serious condition and apparently in no shape for interrogation after being pulled bloody and wounded from a tarp-covered boat in a Watertown backyard. The capture came at the end of a tense Friday that began with his 26-year-old brother, Tamerlan, dying in a gunbattle with police.

U.S. officials said an elite interrogation team would question the Massachusetts college student without reading him his Miranda rights, something that is allowed on a limited basis when the public may be in immediate danger, such as instances in which bombs are planted and ready to go off.

ACLU Executive Director Anthony Romero said the legal exception applies only when there is a continued threat to public safety and is "not an open-ended exception" to the Miranda rule, which guarantees the right to remain silent and the right to an attorney.

The federal public defender's office in Massachusetts said it has agreed to represent Tsarnaev once he is charged. Miriam Conrad, public defender for Massachusetts, said he should have a lawyer appointed as soon as possible because there are "serious issues regarding possible interrogation."

There was no immediate word on when Tsarnaev might be charged and what those charges would be. The twin bombings killed three people and wounded more than 180.

The most serious charge available to federal prosecutors would be the use of a weapon of mass destruction to kill people, which carries a possible death sentence. Massachusetts does not have the death penalty.

President Barack Obama said there are many unanswered questions about the bombing, including whether the Tsarnaev brothers ? ethnic Chechens from southern Russia who had been in the U.S. for about a decade and lived in the Boston area ? had help from others. The president urged people not to rush judgment about their motivations.

Gov. Deval Patrick said Saturday afternoon that Tsarnaev was in serious but stable condition and was probably unable to communicate. Tsarnaev was at Boston's Beth Israel Deaconess Medical Center, where 11 victims of the bombing were still being treated.

"I, and I think all of the law enforcement officials, are hoping for a host of reasons the suspect survives," the governor said after a ceremony at Fenway Park to honor the victims and survivors of the attack. "We have a million questions, and those questions need to be answered."

The all-day manhunt Friday brought the Boston area to a near standstill and put people on edge across the metropolitan area.

The break came around nightfall when a homeowner in Watertown saw blood on his boat, pulled back the tarp and saw a bloody Tsarnaev hiding inside, police said. After an exchange of gunfire, he was seized and taken away in an ambulance.

Raucous celebrations erupted in and around Boston, with chants of "USA! USA!" Residents flooded the streets in relief four days after the two pressure-cooker bombs packed with nails and other shrapnel went off.

Michael Spellman said he bought tickets to Saturday's Red Sox game at Fenway Park to help send a message to the bombers.

"They're not going to stop us from doing things we love to do," he said, sitting a few rows behind home plate. "We're not going to live in fear."

During the long night of violence leading up to the capture, the Tsarnaev brothers killed an MIT police officer, severely wounded another lawman and took part in a furious shootout and car chase in which they hurled explosives at police from a large homemade arsenal, authorities said.

Watertown Police Chief Edward Deveau said one of the explosives was the same type used during the Boston Marathon attack, and authorities later recovered a pressure cooker lid that had embedded in a car down the street. He said the suspects also tossed two grenades before Tamerlan ran out of ammunition and police tackled him.

But while handcuffing him, officers had to dive out of the way as Dzhokhar drove the carjacked Mercedes at them, Deveau said. The SUV dragged Tamerlan's body down the block, he said. Police initially tracked the escaped suspect by a blood trail he left behind a house after abandoning the Mercedes, negotiating his surrender hours later in the boat.

Chechnya, where the Tsarnaev family has roots, has been the scene of two wars between Russian forces and separatists since 1994. That spawned an Islamic insurgency that has carried out deadly bombings in Russia and the region, although not in the West.

Investigators have not offered a motive for the Boston attack. But in interviews with officials and those who knew the Tsarnaevs, a picture has emerged of the older one as someone embittered toward the U.S., increasingly vehement in his Muslim faith and influential over his younger brother.

The Russian FSB intelligence service told the FBI in 2011 about information that Tamerlan Tsarnaev was a follower of radical Islam, two law enforcement officials said Saturday.

According to an FBI news release, a foreign government said that Tamerlan Tsarnaev appeared to be strong believer and that he had changed drastically since 2010 as he prepared to leave the U.S. for travel to the Russian region to join unspecified underground groups.

The FBI did not name the foreign government, but the two officials said it was Russia. The officials spoke on condition of anonymity because they were not authorized to talk about the matter publicly.

The FBI said that in response, it interviewed Tamerlan Tsarnaev and relatives, and did not find any domestic or foreign terrorism activity. The bureau said it looked into such things as his telephone and online activity, his travels and his associations with others.

An uncle of the Tsarnaev brothers said he had a falling-out with Tamerlan over the man's increased commitment to Islam.

Ruslan Tsarni of Montgomery Village, Md., said Tamerlan told him in a 2009 phone conversation that he had chosen "God's business" over work or school. Tsarni said he then contacted a family friend who told him Tsarnaev had been influenced by a recent convert to Islam.

Tsarni said his relationship with his nephew basically ended after that call.

As for Dzhokhar Tsarnaev, "he's been absolutely wasted by his older brother. I mean, he used him. He used him for whatever he's done," Tsarni said.

Albrecht Ammon, a downstairs-apartment neighbor of Tamerlan Tsarnaev in Cambridge, said in an interview that the older brother had strong political views about the U.S. Ammon quoted Tsarnaev as saying that the U.S. uses the Bible as "an excuse for invading other countries."

Tamerlan Tsarnaev studied accounting as a part-time student at Bunker Hill Community College in Boston for three semesters from 2006 to 2008, the school said. He was married with a young daughter. Dzhokhar Tsarnaev was a student at the University of Massachusetts Dartmouth.

As of Saturday, more than 50 victims of the bombing remained hospitalized, three in critical condition.

___

Associated Press writers Denise Lavoie and Steve Peoples in Boston; Michael Hill in Watertown, Mass.; Colleen Long in New York; Pete Yost in Washington; Eric Tucker in Montgomery Village, Md.; and AP Sports Writer Jimmy Golen in Boston contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-21-Boston%20Marathon-Explosions/id-8028ba9c29d34b72879f1d636ff6b6c7

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